Cyber-Physical Systems (CPS) are characterized by the strong interactions between cyber and physical components. CPS system examples include automotive and transportation systems, avionics systems, smart home, building and community, smart battery and energy systems, robotic systems, cyber-physical biochip, wearable devices, and so on. Due to the deeply complex intertwining among different components, CPS designs pose fundamental challenges in multiple aspects such as safety, performance, security, reliability, fault tolerance, extensibility, and energy consumption. Developing innovative design automation techniques, algorithms and tools is imperative to address the unique challenges in CPS design and operation, such as the fast increase of system scale and complexity, the close interactions with dynamic physical environment and human activities, the significant uncertainties in sensor readings, the employment of distributed architectural platforms, and the tight resource and timing constraints. This workshop will present the state-of-the-art research results on the topic of design automation for CPS/IoT systems, introduce practical challenges and promising solutions in various industry sectors, and stimulate CAD researchers to participate in the interdisciplinary CPS/IoT research. In addition to the regular submissions, this workshop will also seek invited submissions/talks from high-profile experts in both academia and industry.